I've been on 4 motorcycling expeditions to the Copper Canyon area in Chihuahua. I think in general, if you are away from the border area, and away from the scuzzy side of town, you have little to worry about. That is, unless you wander into someone's marijuana patch. It helps to have someone along who speaks spanish.
Hoop
2000 DRZ400
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Hoop
2006 XR650R, the dual sport bike
2004 DL1000, the street bike